Granulation Technology is a technology that processes powder, lumpy, molten and other materials into particles of a certain shape and size, which is widely used in medicine, food, chemical industry, pesticide and other fields. Its core is to aggregate materials into particles through physical or chemical methods to improve the fluidity, solubility, stability and other properties of materials.

Granulation Method

• Wet granulation: Powder material is mixed with a binder (liquid) to make the powder bond to form particles. Common methods include swing granulation, high-speed stirring granulation, fluidized bed granulation, etc. It is suitable for materials that are sensitive to heat or need to improve solubility, such as traditional Chinese medicine granules, tablet excipients, etc.

• Dry granulation: Powder is compressed into large flakes directly by mechanical pressure without the need for liquid binders, which are then crushed into granules. It is suitable for materials that are heat-sensitive, hygroscopic or intolerant to liquids, such as antibiotics and some chemical raw materials.

• Spray granulation: Liquid materials (solutions, suspensions, etc.) are dried and granulated at the same time in a hot gas stream through spray drying equipment, and spherical particles are directly obtained. It is suitable for scenarios that require rapid drying and granulation, such as milk powder, enzyme preparations, etc.

• Melt granulation: The material is heated to a molten state, cooled and solidified to form particles, or mixed with other powders and cooled and bonded for granulation. It is suitable for hot melt materials, such as wax, fat-soluble drugs, etc.

Technological Advantages

• Improve material flowability and facilitate subsequent processing (e.g. tableting, packaging);

• Improve the homogeneity of the material and ensure that the ingredients are mixed evenly (e.g. the active ingredient in pharmaceutical tablets);

• Enhance material stability, reduce powder flyover and hygroscopicity;

• Control particle size and density to meet the needs of different products (e.g., particle design for sustained-release formulations).

Typical Applications

• Pharmaceutical field: preparation of granules for tablets and capsules, production of functional granules for sustained/controlled-release preparations;

• Food industry: condiment granules, instant beverage granules, health care product granules, etc.;

• Chemical industry: catalyst particles, detergent particles, fertilizer particles, etc.